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Izon Science Launches the Pulsoid: Single-Particle Precision Without the Complexity

Blog Post

Post publication date:

Monday, April 13, 2026

The new NPS-powered instrument targets lipid nanoparticle researchers who need TEM-level accuracy without the steep learning curve of traditional single-particle systems.

Izon Science has announced the Pulsoid, a next-generation nanoparticle measurement system built around a solid-state silicon nanopore chip. The platform introduces a new measurement technique — Nanopore Pulse Sensing (NPS) — designed to deliver high-resolution, single-particle analysis of size, concentration, and zeta potential in a fast, accessible workflow that requires no specialist expertise to operate.
The instrument comes as global investment in lipid nanoparticle technologies accelerates, driven by the expanding market for mRNA vaccines, cancer therapies, and gene delivery applications. Izon, which has sold around 1,000 instruments worldwide with its existing Tunable Resistive Pulse Sensing (TRPS) platform, built the Pulsoid directly in response to the practical limitations its customers encountered in the field.

"Progress in LNP-based drug delivery and gene therapy depends on data that accurately reflects what is happening at the particle level. Averaged measurements can miss the very changes — in size distribution, concentration or surface charge — that matter most during formulation development and stability testing."

— Hans van der Voorn, CEO, Izon Science

A different architecture

Where the existing Exoid platform relies on a flexible, tunable polymer nanopore that requires frequent recalibration and hands-on adjustment, the Pulsoid uses a precision-manufactured silicon chip with a fixed pore geometry. The result is a system that eliminates the stretch-adjustment step entirely, reduces between-user variability, and — according to Izon — delivers approximately twice the measurement throughput of the Exoid, with individual samples running in two to five minutes.
Size accuracy has been validated at 100% ± 2% against NIST-traceable polystyrene standards, with agreement reaching 99.7% relative to TEM values — widely regarded as the reference method for nanoparticle sizing. Unlike TEM, which evaluates only a small number of particles, the Pulsoid measures approximately 500 particles per run, producing statistically robust distributions in minutes.

Zeta potential for every pore

One notable difference from the Exoid is that all Pulsoid nanopores support simultaneous zeta potential measurement — no special consumable required. The system measures surface charge density on a particle-by-particle basis, providing resolution into charge distributions and subpopulations that ensemble techniques such as Phase Analysis Light Scattering (PALS) average away. This is particularly relevant for polydisperse LNP samples where formulation stability, encapsulation efficiency, and aggregation behaviour can vary significantly across the particle population.

Positioning and roadmap

The Pulsoid now ships with a single chip size (designated 80 nm) covering particles from 40 to 140 nm. At least two larger chip sizes are expected within the coming months, which will also improve compatibility with extracellular vesicle samples prone to pore blockage. Izon is additionally testing a calibration-free measurement approach with the aim of removing that step entirely in a future release.
The instrument is positioned to compete directly with DLS and NanoTracking Analysis (NTA) systems in LNP development workflows, offering single-particle resolution without the complexity historically associated with nanopore-based techniques. The Exoid remains in the catalogue for researchers requiring maximum versatility across complex or highly heterogeneous biological samples.