Publication: "Advanced nanomedicine characterization by DLS and AF4-UV-MALS: Application to a HIV nanovaccine"

Here's a recent publication about the characterization of an HIV nanoparticle-based vaccine using DLS and AF4. This research was conducted by several groups in France and Spain and they used Cordouan's VASCO2 and WALLIS.

From the paper's Abstract: "Nanoformulations are complex systems where physicochemical properties determine their therapeutic efficacy and safety. In the case of nanovaccines, particle size and shape play a crucial role on the immune response generated. Furthermore, the antigen’s integrity is also a key aspect to control when producing a nanovaccine. The determination of allthose physicochemical properties is still an analytical challenge and the lack of well-established methods hinders the access of new therapeutics to the market. In this work, robust methods for the characterization of a novel HIV nanoparticle-based vaccine produced in good manufacturing practice (GMPs)-like environment were developed. With slightly polydisperse particles (< 0.2) close to 180 nm of size, batch-mode Dynamic Light Scattering (DLS) was validated to be used as a quality control technique in the pilot production plant.  [...]"